Research Interests
Chromatin architecture around origins of replication
We study the establishment of chromatin architecture around replication origins and its impact on genome-wide replication. A diverse array of methodologies is employed to investigate this phenomenon, with the objective of subsequently extending these efforts to elucidate the underlying mechanisms in the human system.
The involvement of the cell cycle machinery
We also examine the role of the cell cycle machinery in regulating chromatin function at the sites of DNA replication. In particular, our research focuses on the cell cycle regulators Cyclin-Dependent Kinase (CDK) and Dbf4-Dependent Kinase (DDK), and their influence on chromatin modifying factors at origins under normal replication conditions. Furthermore, we are interested in the manner in which chromatin influences the response to replication stress and the potential regulation of chromatin factors by checkpoint kinases.